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Metagenics

SPM Active New & Improved

SPM Active New & Improved

Regular price $81.00
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60 softgels

Targeted support for minor pain relief*

Specialized pro-resolving mediators (SPMs) help promote resolution of physical stress after strenuous physical exertion. SPM Active® supports the body’s natural capacity to respond to physical challenges.*

  • The only SPM supplement with human clinical data with demonstrated results*
  • Helps promote tissue health
  • Clinically demonstrated improvement in joint comfort, sleep, and mood†*
  • Metagenics set the standard for defining SPMs based on activity for use in nutraceutical formulas in collaboration with world-renowned SPM experts.
  • Our revolutionary and exclusive formula was developed through advanced fractionation technology featuring standardized levels of 17-HDHA and 18-HEPE found in marine lipids.
  • Supplementing with SPMs may help facilitate the body’s natural resolution process and completion of its response to physical challenges.*

Study of 149 subjects who consumed an SPM product identical to SPM Active® (2 softgels) for 1 month and 120 subjects who consumed the SPM product for 3 months (2 softgels for one month and 1 softgel for the following two months).


In the past, it was thought the resolution of the immune response was a passive process. However, recent groundbreaking research has identified a structured and orderly system which actively resolves the immune response. During the resolution phase, specialized pro-resolving mediators (SPMs) are produced at the affected tissue site and function as “resolution agonists,” orchestrating the resolution-related activities and helping to facilitate this response toward homeostasis.
Individual levels of SPMs can differ and can vary due to: 4,5
•Aging process
•Dietary patterns
•Physical fitness
•Other stressors

Ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, andmackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin,and water), and silica. Contains: Fish (anchovy, sardine, and mackerel).

Directions: Take two softgels once daily or as directed by your healthcare practitioner.

This product is non-GMO and gluten-free.

Caution: If pregnant, nursing, or taking nutritional supplements or medications, consult your healthcare practitioner before use. Keep out of the reach of children.

Storage: Keep tightly closed in a cool, dry place.

Tamper Evident:Do not use if safety seal is missing or broken

Lipinova is a registered trademark of Solutex.

*Percent Daily Values are based on a 2,000 calorie diet.

**Daily Value not established.

US Patents 11,077,083 and 11,077,084